多黏菌素 B 治疗台湾地区住院成年严重葡萄球菌感染患者的安全性和疗效。
Safety and efficacy of daptomycin for the treatment of hospitalized adult patients in Taiwan with severe staphylococcal infections.
机构信息
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
出版信息
J Microbiol Immunol Infect. 2012 Feb;45(1):52-7. doi: 10.1016/j.jmii.2011.09.018. Epub 2011 Dec 6.
BACKGROUND AND PURPOSE
The safety and efficacy of treating serious infections caused by Staphylococcus aureus with daptomycin in a Taiwanese population were studied.
METHODS
A retrospective, multicenter study was performed in Taiwan between December 2007 and June 2009. This study included adult hospitalized patients who had received intravenous daptomycin therapy for infections caused by S aureus. All patients were followed until discharge from the hospital or death.
RESULTS
A total of 52 patients (males, n=44; median age: 62 years) were evaluated. Infections included complicated skin and soft-tissue infections (n=14), catheter-related bacteremia (n=14), osteomyelitis and septic arthritis (n=12), endovascular infections and endocarditis (n=11), and urinary tract infections (n=1). Overall, 47 (90.4%) patients were successfully treated and their clinical symptoms were resolved. Adverse effects related to daptomycin were detected in nine patients, but none were required to discontinue daptomycin.
CONCLUSION
The results support daptomycin as an effective and safe treatment for staphylococcal infections in Taiwanese populations.
背景与目的
研究达托霉素治疗台湾人群金黄色葡萄球菌引起的严重感染的安全性和疗效。
方法
2007 年 12 月至 2009 年 6 月，在台湾进行了一项回顾性、多中心研究。该研究纳入了接受达托霉素治疗金黄色葡萄球菌感染的住院成年患者。所有患者均随访至出院或死亡。
结果
共评估了 52 例患者（男性 44 例；中位年龄：62 岁）。感染包括复杂性皮肤和软组织感染（n=14）、导管相关菌血症（n=14）、骨髓炎和化脓性关节炎（n=12）、血管内感染和心内膜炎（n=11）和尿路感染（n=1）。总体而言，47（90.4%）例患者成功治疗，临床症状得到缓解。9 例患者出现与达托霉素相关的不良反应，但均无需停用达托霉素。
结论
结果支持达托霉素作为治疗台湾人群葡萄球菌感染的有效且安全的治疗方法。
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