Department of Neurology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, Chongqing 400042, PR China.
Thromb Res. 2012 Oct;130(4):654-60. doi: 10.1016/j.thromres.2011.11.030. Epub 2011 Dec 9.
Epidemiological studies have evaluated the association between factor XIII-A (FXIII-A) Val34Leu polymorphism and risk of ischemic stroke, but the results remain inconclusive. This meta-analysis was therefore designed to clarify these controversies.
Systematic searches of electronic databases Embase, PubMed and Web of Science, as well as hand searching of the references of identified articles and the meeting abstracts were performed. Study selection, data abstraction and study quality evaluation (using the Newcastle-Ottawa Scale, NOS) were independently conducted in duplicate. Statistical analyses were performed using software Review Manager (Version 5.1.2) and Stata (Version 11.0). The pooled odds ratios (ORs) with 95% confidence intervals (95%CIs) were performed. Fixed or random effects model was separately used depending on the heterogeneity between studies. Publication bias was tested by funnel plot, Egger's regression test and Begg's test. Sensitivity analysis was conducted by limiting the meta-analysis to the high quality studies (NOS score≥8).
A total of 16 studies including 3,807 cases and 4,993 controls were combined showing no evidence of association between FXIII-A Val34Leu polymorphism and ischemic stroke (for Val/Leu vs. Val/Val : OR=0.95, 95%CI=0.77-1.16; for Leu/Leu vs. Val/Val: OR=0.90, 95%CI=0.73-1.11; for dominant model: OR=0.97, 95%CI=0.81-1.17; for recessive model: OR=0.95, 95%CI=0.77-1.17). In the subgroup analyses by study design, ethnicity and specific subtypes (small-vessel occlusive ischemic stroke and large-artery atherosclerotic ischemic stroke ), there was lack of evidence for the association.
This meta-analysis indicates that there is no evidence for association between factor XIII-A Val34Leu polymorphism and ischemic stroke.
流行病学研究评估了因子 XIII-A（FXIII-A）Val34Leu 多态性与缺血性脑卒中风险之间的关联，但结果仍存在争议。因此，本荟萃分析旨在阐明这些争议。
系统检索电子数据库 Embase、PubMed 和 Web of Science，并手动检索已确定文章的参考文献和会议摘要。研究选择、数据提取和研究质量评估（使用纽卡斯尔-渥太华量表，NOS）由两人独立进行。使用 Review Manager（版本 5.1.2）和 Stata（版本 11.0）软件进行统计分析。使用合并的 odds ratios（ORs）及其 95%置信区间（95%CI）进行固定或随机效应模型分析。根据研究之间的异质性，分别使用固定或随机效应模型。通过漏斗图、Egger 回归检验和 Begg 检验测试发表偏倚。通过限制荟萃分析为高质量研究（NOS 评分≥8）来进行敏感性分析。
共纳入 16 项研究，包括 3807 例病例和 4993 例对照，结果显示 FXIII-A Val34Leu 多态性与缺血性脑卒中之间无关联（Val/Leu 与 Val/Val：OR=0.95，95%CI=0.77-1.16；Leu/Leu 与 Val/Val：OR=0.90，95%CI=0.73-1.11；显性模型：OR=0.97，95%CI=0.81-1.17；隐性模型：OR=0.95，95%CI=0.77-1.17）。按研究设计、种族和特定亚型（小血管闭塞性缺血性卒中和大动脉粥样硬化性缺血性卒中等）进行亚组分析，均缺乏关联的证据。
本荟萃分析表明，FXIII-A Val34Leu 多态性与缺血性脑卒中之间无关联。
