Ethel Austin Martin Program in Human Nutrition, South Dakota State University, Brookings, SD 57007, USA.
Bone. 2012 Mar;50(3):638-42. doi: 10.1016/j.bone.2011.11.011. Epub 2011 Nov 30.
There are conflicting reports on the influence of lean and fat mass on bone accrual during childhood. No infant's studies have been reported that describe the influence of changes in body composition with changes in bone accrual during the first year of life. The objective of this research was to test the hypothesis that greater gains in lean mass will have a positive effect on bone mineral content (BMC) accrual, while greater gains in fat mass will have a negative effect on BMC accrual in infants. Longitudinal data from 3 previous infant studies were used. Linear mixed models, adjusting for age, sex, dietary calcium, and length were used to investigate longitudinal and cross-sectional associations between total body BMC and lean and fat mass in the individual studies and in a combined analysis. In both individual and combined analyses, we found that lean and fat mass were positively associated with whole body BMC accrual (all, P<0.001). The cross-sectional association of BMC and dietary calcium was negative in one study (P<0.05). No differences in BMC change between sexes were observed in three studies. Our results showed positive cross-sectional and longitudinal associations between total body BMC and lean mass in infants. In contradiction to our hypothesis for fat mass, we found a positive cross-sectional and longitudinal association between total body BMC and fat mass in infants.
关于瘦体重和脂肪量对儿童期骨量积累的影响，目前存在相互矛盾的报告。尚无研究描述婴儿期身体成分的变化与生命第一年骨量积累的变化之间的关系。本研究的目的是验证以下假设：瘦体重的增加将对骨矿物质含量（BMC）的积累产生积极影响，而脂肪量的增加将对婴儿的 BMC 积累产生负面影响。本研究使用了之前 3 项婴儿研究的纵向数据。采用线性混合模型，根据年龄、性别、膳食钙和身长进行调整，以研究个体研究和综合分析中全身 BMC 与瘦体重和脂肪量之间的纵向和横断面关系。在个体和综合分析中，我们发现瘦体重和脂肪量与全身 BMC 积累呈正相关（均 P<0.001）。一项研究中 BMC 与膳食钙的横断面相关性为负（P<0.05）。在三项研究中，未观察到性别间 BMC 变化的差异。我们的结果表明，婴儿的全身 BMC 与瘦体重之间存在横断面和纵向的正相关关系。与我们对脂肪量的假设相反，我们发现婴儿的全身 BMC 与脂肪量之间存在横断面和纵向的正相关关系。
