Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, London W12 0NN, UK.
Curr Opin Genet Dev. 2012 Apr;22(2):93-100. doi: 10.1016/j.gde.2011.11.003. Epub 2011 Dec 10.
Cohesin defines the topology of chromosomes in mitosis and meiosis by holding sister chromatids together; more recently a role for cohesin in chromatin organisation and gene expression in interphase has emerged.
黏连蛋白通过将姐妹染色单体保持在一起定义了有丝分裂和减数分裂中染色体的拓扑结构;最近,黏连蛋白在染色质组织和有丝分裂间期基因表达中的作用也显现出来。