黏连蛋白：一种多功能的染色质黏合剂。

Cohesin: a multi-purpose chromatin glue.

机构信息

Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

出版信息

J Mol Cell Biol. 2009 Dec;1(2):58-60. doi: 10.1093/jmcb/mjp014. Epub 2009 Aug 14.

DOI:10.1093/jmcb/mjp014

PMID:19684050

Abstract

Long thought to be the glue responsible for holding sister chromatids together, cohesin has been found to be stickier than previously thought. Recent discoveries point to cohesin having a role in transcription regulation by mediating long-distance intra-chromosomal interactions.

摘要

长期以来，黏连蛋白被认为是将姐妹染色单体黏在一起的“胶水”，但它的黏性比之前认为的更强。最近的发现表明，黏连蛋白通过介导染色体内部的长距离相互作用，在转录调控中发挥作用。