Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
Anaerobe. 2012 Apr;18(2):249-53. doi: 10.1016/j.anaerobe.2011.11.005. Epub 2011 Dec 2.
The human normal microflora is relatively stable at each ecological habitat under normal circumstances and acts as a barrier against colonization by potentially pathogenic microorganisms and against overgrowth of already present opportunistic microorganisms. Administration of antimicrobial agents causes disturbances in the ecological balance between the host and the normal microflora. The risk of emergence and spread of resistant strains between patients and dissemination of resistant determinants between microorganisms is reduced if colonization resistance is not disturbed by antimicrobial agents. In this article, the potential ecological effects of administration of new antimicrobial agents on the intestinal and oropharyngeal microflora are summarized. The review is based on clinical studies published during the past 10 years.
正常情况下，人类正常微生物群在每个生态栖息地相对稳定，作为一种屏障，防止潜在的致病性微生物定植和已经存在的机会性微生物过度生长。抗菌药物的使用会干扰宿主与正常微生物群之间的生态平衡。如果抗菌药物不干扰定植抵抗力，则可以降低患者之间耐药菌株的出现和传播以及微生物之间耐药决定因素传播的风险。本文总结了新抗菌药物给药对肠道和口咽微生物群的潜在生态影响。该综述基于过去 10 年发表的临床研究。
