鸡二腹肌标本中巴哈马毒蛛蛇毒的神经肌肉活性。

Neuromuscular activity of Bothrops alcatraz snake venom in chick biventer cervicis preparations.

机构信息

Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), P.O. Box 6111, 13083-970 Campinas, SP, Brazil.

出版信息

Toxicon. 2012 Feb;59(2):294-9. doi: 10.1016/j.toxicon.2011.11.011. Epub 2011 Dec 1.

DOI:10.1016/j.toxicon.2011.11.011

PMID:22155137

Abstract

Venom (10-100 μg/ml) from Bothrops alcatraz, a pitviper from the Alcatrazes Archipelago off the coast of southeastern Brazil, caused progressive, irreversible neuromuscular blockade in chick isolated biventer cervicis preparations. The venom also inhibited contractures to exogenous ACh (110 μM) and KCl (20 mM), caused myofiber damage and increased creatine kinase release. Commercial bothropic antivenom raised against mainland Bothrops species neutralized the neuromuscular activity, depending on the venom concentration.

摘要

来自巴西东南沿海阿尔卡特拉斯群岛的矛头蝮属毒蛇（10-100μg/ml）在鸡的分离双颈椎肌制备物中引起进行性、不可逆的神经肌肉阻滞。该毒液还抑制了对外源 ACh（110μM）和 KCl（20mM）的收缩反应，导致肌纤维损伤和肌酸激酶释放增加。针对大陆矛头蝮属物种的商业抗蛇毒血清中和了神经肌肉活性，这取决于毒液浓度。