Metabolic activation of quercetin mutagenicity.
作者信息
Vrijsen R, Michotte Y, Boeyé A
机构信息
Department of Microbiology and Hygiene, Vrije Universiteit Brussel, Belgium.
出版信息
Mutat Res. 1990 Oct;232(2):243-8. doi: 10.1016/0027-5107(90)90130-v.
PMID:2215534
Abstract
The mutagenicity of quercetin was reinvestigated using the Salmonella/microsome test. The mutagenicity of quercetin was enhanced by the cytosolic fraction of liver extract (S100), or by ascorbate, and even more by the complete liver supernatant (S9) in the presence of cofactors (NADP and glucose-6-phosphate). The formation of metabolites by the S9 enzymes was demonstrated by reverse-phase HPLC.
摘要
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