Makaridze T, Mardaleishvili K
Georgian-German Specialized Oncological Clinic, Tbilisi, Georgia.
Georgian Med News. 2011 Oct(199):20-9.
The aim of the study is to establish the role of endocrine disturbances in development of malignant tumors in patients with thyroid gland and reproductive system pathology. We studied 207 patients with synchronic and metachronic development of thyroid gland and reproductive system benign tumors. The patients' average age was 35-58 years. According to study the following aspects were determined: clinical and hormonal aspect of thyroid gland and reproductive system benign tumor disease coincidence, analyses of thyroid gland and reproductive system pre-cancer disease pathogenesis, neuroendocrine relations-like increased thyrotrophic hormone secretion causes strengthening of prolactin secretion, which depresses luteinizing hormone release and increases production of follicular stimulating hormone. It has been proved that fibromyomas absolute hyperestrogenemia which develops during hypersecretion of follicular stimulating hormone (FSH) plays a role in etiology of uterine Gonadoliberin hypersecretion, especially follicular stimulating hormone FSH and corpus luteum deficiency is very important in development of ovarian pre-cancer and cancer diseases.
该研究的目的是确定内分泌紊乱在甲状腺和生殖系统疾病患者恶性肿瘤发生中的作用。我们研究了207例甲状腺和生殖系统良性肿瘤同步和异时发生的患者。患者的平均年龄为35至58岁。根据研究确定了以下方面：甲状腺和生殖系统良性肿瘤疾病并发的临床和激素方面，甲状腺和生殖系统癌前疾病发病机制的分析，神经内分泌关系，如促甲状腺激素分泌增加导致催乳素分泌增强，从而抑制促黄体生成素释放并增加促卵泡生成素的产生。已证实，在促卵泡生成素（FSH）分泌过多期间发生的纤维瘤绝对高雌激素血症在子宫促性腺激素释放激素分泌过多的病因中起作用，特别是促卵泡生成素FSH和黄体功能不足在卵巢癌前病变和癌症疾病的发生中非常重要。
