Adolescent Medicine, Department of Obstetrics, Gynecology and Pediatrics, Santa Chiara University Hospital, Pisa, Italy.
Horm Res Paediatr. 2011;76(6):428-33. doi: 10.1159/000334162. Epub 2011 Nov 29.
Complete androgen insensitivity syndrome (CAIS) represents a main disorder of sex development. Women with CAIS may have their gonads removed before, during or after adolescence, thus requiring hormonal replacement therapy to induce puberty and/or maintain secondary sexual characteristics, to optimize bone mass accrual, and to promote physical and social well-being. Usually estrogens are used for this purpose, but formulations and doses should be better defined in multicentric prospective studies. Some women started testostosterone as hormonal replacement therapy, but this practice remains anecdotal. Bone health remains a crucial aspect in the management of persons with CAIS, but few sound data are available to guide clinical practice.
完全雄激素不敏感综合征（CAIS）是一种主要的性发育障碍。CAIS 女性可能在青春期前、青春期期间或青春期后切除性腺，因此需要激素替代疗法来诱导青春期和/或维持第二性征，以优化骨量积累，并促进身体和社会福祉。通常使用雌激素来达到这个目的，但在多中心前瞻性研究中应更好地定义制剂和剂量。一些女性开始使用睾酮作为激素替代疗法，但这种做法仍属轶事。骨骼健康仍然是 CAIS 患者管理的一个关键方面，但很少有可靠的数据来指导临床实践。
