Department of Chemistry, Brown University, Providence, RI 02912, USA.
IEEE Trans Nanobioscience. 2012 Mar;11(1):46-53. doi: 10.1109/TNB.2011.2176509. Epub 2011 Dec 5.
Magnetic nanoparticles (MNPs) have been studied widely as a powerful diagnostic probe and therapeutic agent for biomedical applications. In recent years, they are also found to be sensitive to magnetoresistive (MR) devices and MNP-MR biochips are predicted to be more affordable, portable and sensitive than the conventional optical detection methods. In this MNP-MR biochip design, MNP probes are required to have high magnetic moment, high susceptibility, and be target-specific. This review summarizes recent advances in chemical syntheses and functionalization of MNPs with controlled magnetic properties for sensitive MR detection and for bio-sensing applications.
磁性纳米粒子 (MNPs) 已被广泛研究作为一种强大的诊断探针和治疗剂，用于生物医学应用。近年来，它们也被发现对磁阻 (MR) 器件敏感，并且预测 MNP-MR 生物芯片比传统的光学检测方法更经济实惠、便携和敏感。在这种 MNP-MR 生物芯片设计中，需要具有高磁矩、高磁化率和靶向特异性的 MNP 探针。本综述总结了近年来在具有可控磁性的 MNPs 的化学合成和功能化方面的进展，用于灵敏的 MR 检测和生物传感应用。
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