Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011-5640, USA.
Exerc Sport Sci Rev. 2012 Apr;40(2):73-8. doi: 10.1097/JES.0b013e31824580c6.
Several properties of muscle defy explanation solely based on the sliding filament-swinging cross-bridge theory. Indeed, muscle behaves as though there is a dynamic "spring" within the sarcomeres. We propose a new "winding filament" mechanism for how titin acts, in conjunction with the cross-bridges, as a force-dependent spring. The addition of titin into active sarcomeres resolves many puzzling muscle characteristics.
有几项肌肉特性仅根据滑行丝-摆动横桥理论是无法解释的。事实上，肌肉的行为就好像肌节内有一个动态的“弹簧”。我们提出了一种新的“缠绕丝”机制，用于解释连接肌球蛋白横桥的肌联蛋白如何作为力依赖的弹簧发挥作用。肌联蛋白的加入解决了许多令人困惑的肌肉特性。
