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2011 年多囊肾病:将点连接起来以实现多囊肾病治疗。

Polycystic kidney disease in 2011: Connecting the dots toward a polycystic kidney disease therapy.

机构信息

Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.

出版信息

Nat Rev Nephrol. 2011 Dec 13;8(2):66-8. doi: 10.1038/nrneph.2011.196.

Abstract

Understanding the complex interactions between the various pathways disrupted in polycystic kidney and liver disease is essential to identify and optimize therapies for these disorders. Studies published in the past year have demonstrated a functional interaction between the main proteins implicated in these diseases and identified novel therapeutic approaches.

摘要

了解多囊肾病和肝病中各种途径紊乱的复杂相互作用对于确定和优化这些疾病的治疗方法至关重要。过去一年发表的研究表明,这些疾病中主要涉及的蛋白质之间存在功能相互作用,并确定了新的治疗方法。

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本文引用的文献

1
Macrophages promote cyst growth in polycystic kidney disease.巨噬细胞促进多囊肾病囊肿生长。
J Am Soc Nephrol. 2011 Oct;22(10):1809-14. doi: 10.1681/ASN.2011010084. Epub 2011 Sep 15.
6
Polycystin-1 regulates STAT activity by a dual mechanism.多囊蛋白-1通过双重机制调节 STAT 活性。
Proc Natl Acad Sci U S A. 2011 May 10;108(19):7985-90. doi: 10.1073/pnas.1103816108. Epub 2011 Apr 25.
8
Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis.激活 AMP 激活的蛋白激酶(AMPK)可减缓肾囊肿的发生。
Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2462-7. doi: 10.1073/pnas.1011498108. Epub 2011 Jan 24.

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