General Dermatology, Medical University of Graz, Graz, Austria.
J Invest Dermatol. 2012 Jan;132(1):15-7. doi: 10.1038/jid.2011.361.
The strict control of the T-cell receptor repertoire is essential for prevention of autoimmune diseases. The repertoire of T cells is primarily formed in the thymus through positive and negative selection. The risk of an incomplete removal of autoreactive T cells necessitates additional means to maintain peripheral tolerance. There is increasing evidence that the interferon (IFN)-γ-inducible lysosomal thiol reductase (GILT) allows peripheral tolerance to a melanocyte differentiation antigen by induction of specific regulatory T cells.
严格控制 T 细胞受体库对于预防自身免疫性疾病至关重要。T 细胞库主要通过阳性和阴性选择在胸腺中形成。由于不完全清除自身反应性 T 细胞的风险，因此需要其他手段来维持外周耐受。越来越多的证据表明，干扰素 (IFN)-γ诱导的溶酶体硫醇还原酶 (GILT) 通过诱导特异性调节性 T 细胞允许对黑素细胞分化抗原产生外周耐受。
