Paroxetine and the electroencephalogram.

Electroencephalograms, recorded before and after 4 weeks' treatment with parox etine or placebo, were assessed blind to patient, treatment and treatment interval. No signifi cant differences were found between the paroxetine and the placebo groups. There were no signs of drowsiness or epileptiform activity in the recordings of patients receiving either drug or placebo. The results are discussed in relation to those of pharmacological studies in animals, psychomotor testing and electroencephalographic studies in humans.