Eliashiv S, Wirguin I, Brenner T, Argov Z
Department of Neurology, Hadassah University Hospital, Jerusalem, Israel.
Neurology. 1990 Oct;40(10):1623-5. doi: 10.1212/wnl.40.10.1623.
After observing a 72-year-old myasthenic patient develop an acute myasthenic exacerbation following the administration of routine diagnostic IV contrast material, an observation rarely described in the literature, we used the experimental autoimmune myasthenia gravis model in rabbits injected with a contrast agent to simulate the situation. There was significant worsening of the decremental response to 3 Hz repetitive nerve stimulation from 40 +/- 29% to 55 +/- 27% following the IV administration of contrast agent at doses similar to those used in humans. IV calcium partially reversed this aggravation. Caution is merited when myasthenic patients are administered contrast media.
在观察到一名72岁的重症肌无力患者在静脉注射常规诊断用造影剂后出现急性重症肌无力加重（这是文献中很少描述的一种情况）后，我们使用在兔身上注射造影剂的实验性自身免疫性重症肌无力模型来模拟这种情况。静脉注射与人使用剂量相似的造影剂后，对3赫兹重复神经刺激的递减反应从40±29%显著恶化至55±27%。静脉注射钙剂可部分逆转这种加重情况。给重症肌无力患者使用造影剂时应谨慎。
