Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine, Rochester, NY 14642, USA.
Hematology Am Soc Hematol Educ Program. 2011;2011:470-4. doi: 10.1182/asheducation-2011.1.470.
Our appreciation of the roles that platelets play in vascular biology is constantly expanding. One of the major roles of platelets is in initiating and accelerating immune responses. Platelet transfusion may be associated with adverse inflammatory outcomes manifested as fever, discomfort, tachycardia, and respiratory issues. This may in part be due to immune mediators either expressed by activated platelets or released into the platelet media during platelet storage. This review will highlight some more recent knowledge gained regarding the platelet storage lesion and potential mediators of platelet transfusion reactions.
我们对血小板在血管生物学中所扮演的角色的认识在不断扩展。血小板的主要作用之一是启动和加速免疫反应。血小板输注可能与不良的炎症结果相关，表现为发热、不适、心动过速和呼吸问题。这可能部分是由于激活的血小板表达的免疫介质，或者在血小板储存过程中释放到血小板介质中。这篇综述将重点介绍一些关于血小板储存损伤和血小板输注反应潜在介质的最新知识。
