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急性前循环卒中静脉溶栓后血管内机械再通:新型临时支架的影响。

Endovascular mechanical recanalisation after intravenous thrombolysis in acute anterior circulation stroke: the impact of a new temporary stent.

机构信息

Department of Neuroradiology, University of Munich, Klinikum Grosshadern, Marchioninistr. 15, 81377, Munich, Germany.

出版信息

Cardiovasc Intervent Radiol. 2012 Dec;35(6):1326-31. doi: 10.1007/s00270-011-0317-5. Epub 2011 Dec 9.

Abstract

PURPOSE

Treatment of acute stroke by endovascular mechanical recanalisation (EMR) has shown promising results and continues to be further refined. We evaluated the impact of a temporary stent compared with our results using other mechanical devices.

MATERIALS AND METHODS

We analysed clinical and radiological data of all patients who were treated by EMR after intravenous thrombolysis for acute carotid T- and middle-cerebral artery (M1) occlusions at our centre between 2007 and 2011. A comparison was performed between those patients in whom solely the stent-retriever was applied (group S) and those treated with other devices (group C).

RESULTS

We identified 14 patients for group S and 16 patients for group C. Mean age, National Institute of Health Stroke Scale score, and time to treatment were 67.1 years and 16.5 and 4.0 h for group S and 61.1 years and 17.6 and 4.5 h for group C, respectively. Successful recanalisation (thrombolysis in cerebral infarction scores ≥IIb) was achieved in 93% of patients in group S and 56% of patients in group C (P < 0.05). Mean recanalisation times for M1 occlusions were 23 min (group S) and 29 min (group C) and for carotid-T occlusions were 39 min (group S) and 50 min (group C), and 45% of the patients in group S and 33% in group C had a favourable outcome (Modified Rankin Scale score ≤2).

CONCLUSION

The findings suggest an improvement in recanalisation success by the application of a temporary stent compared with previously used devices. These results are to be confirmed by larger studies.

摘要

目的

血管内机械再通(EMR)治疗急性中风的效果令人振奋,并在持续改进中。我们评估了临时支架与我们使用其他机械装置的结果相比的影响。

材料与方法

我们分析了 2007 年至 2011 年期间,我们中心在静脉溶栓治疗急性颈内动脉 T 型和大脑中动脉(M1)闭塞后,通过 EMR 治疗的所有患者的临床和影像学数据。对仅使用支架取栓器的患者(S 组)和使用其他器械治疗的患者(C 组)进行了比较。

结果

S 组有 14 例患者,C 组有 16 例患者。S 组患者的平均年龄、国立卫生研究院卒中量表评分和治疗时间分别为 67.1 岁、16.5 分和 4.0 小时,C 组患者的平均年龄、国立卫生研究院卒中量表评分和治疗时间分别为 61.1 岁、17.6 分和 4.5 小时。S 组患者的再通率(血栓溶解脑梗死评分≥Ⅱb)为 93%,C 组患者为 56%(P<0.05)。M1 闭塞的平均再通时间为 S 组 23 分钟,C 组 29 分钟;颈内动脉-T 闭塞的平均再通时间为 S 组 39 分钟,C 组 50 分钟;S 组 45%的患者和 C 组 33%的患者预后良好(改良 Rankin 量表评分≤2)。

结论

与以往使用的器械相比,应用临时支架可提高再通成功率。这些结果有待更大规模的研究证实。

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