Department of Endocrinology and Metabolism, Tokyo Metropolitan Toshima Hospital, 33-1 Sakaecho Itabashiku, Tokyo, 173-0015, Japan.
Biochem Genet. 2012 Jun;50(5-6):389-96. doi: 10.1007/s10528-011-9483-z. Epub 2011 Dec 9.
This study investigates aromatase gene polymorphism, which might influence bone strength in terms of mineral density and quality. We explored the relationship between CYP19 polymorphisms and vertebral fractures in postmenopausal Japanese women. In addition, we compared estrogen and testosterone levels in Japanese postmenopausal women with and without fractures. Osteoporotic postmenopausal women showed higher incidences of vertebral fractures than osteopenic women or women with normal lumbar bone mineral density (L2-4 BMD). Estrogen concentrations in postmenopausal women were associated with BMD; however, no association was found between sex hormone levels and the presence of fractures. The C allele rs2470152 was significantly associated with increased risk of vertebral fractures (P = 0.04), whereas none of the CYP19 polymorphisms showed differences in sex steroid levels between subjects with and without fractures. Allelic variants of aromatase genes appear to interact to influence the risk of vertebral fractures in postmenopausal Japanese women.
本研究调查了细胞色素 P450 家族 19 亚单位多肽 1（CYP19）基因多态性，其可能会影响骨密度和质量等方面的骨强度。我们探讨了 CYP19 多态性与绝经后日本女性椎体骨折之间的关系。此外，我们比较了伴有和不伴有骨折的绝经后日本女性的雌激素和睾酮水平。骨质疏松症绝经后女性的椎体骨折发生率高于骨量减少或腰椎骨密度（L2-4 BMD）正常的女性。绝经后女性的雌激素浓度与 BMD 相关；然而，性激素水平与骨折的发生之间未发现关联。C 等位基因 rs2470152 与椎体骨折风险增加显著相关（P = 0.04），而 CYP19 多态性的任何一种均未显示出骨折患者与无骨折患者之间的性激素水平存在差异。芳香化酶基因的等位变体似乎相互作用，影响绝经后日本女性的椎体骨折风险。
