异嗜性小鼠白血病病毒在DBA/2和C57BL/6品系之间的遗传杂交中作为细胞表面gp70的表达。
Expression of xenotropic murine leukemia viruses as cell-surface gp70 in genetic crosses between strains DBA/2 and C57BL/6.
作者信息
Morse H C, Chused T M, Hartley J W, Mathieson B J, Sharrow S O, Taylor B A
出版信息
J Exp Med. 1979 May 1;149(5):1183-96. doi: 10.1084/jem.149.5.1183.
Abstract
Flow microfluorometry was used to assess levels of xenotropic murine leukemia virus envelope-related cell-surface antigens (XenCSA) expressed on lymphocytes of mice derived from crosses between C57BL/6 (B6) and DBA/2 (D2); 24 recombinant inbred strains (BXD RIs) and 62 backcross mice were studied. The results suggest that XenCSA expression is affected by more than one gene but that the predominant influence is exerted by a single semidominant gene apparently located on chromosome 4 at or in close proximity to the Fv-1 locus. Studies of spontaneous virus production in B6D2F1 X D2 mice suggest that this locus may also affect production by spleen cells of xenotropic MuLV registering in a fluorescent antibody assay of mink lung cells.
摘要
采用流式微量荧光测定法评估源自C57BL/6（B6）和DBA/2（D2）杂交后代小鼠淋巴细胞上表达的嗜异性小鼠白血病病毒包膜相关细胞表面抗原（XenCSA）水平；研究了24个重组近交系（BXD RI）和62只回交小鼠。结果表明，XenCSA表达受多个基因影响，但主要影响由一个半显性基因施加，该基因显然位于4号染色体上Fv-1位点或其附近。对B6D2F1×D2小鼠自发病毒产生的研究表明，该位点可能也影响脾脏细胞产生嗜异性MuLV，在貂肺细胞的荧光抗体测定中可检测到这种病毒。
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