Graduate Program in Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
J Neurovirol. 2011 Dec;17(6):528-34. doi: 10.1007/s13365-011-0062-1. Epub 2011 Dec 8.
A hallmark of herpes viruses is their capacity to cause recurrent disease. Recurrences of herpes simplex virus (HSV)-1 disease do not result from reinfection from external sources, but rather from reactivation of virus that is maintained in a latent state in sensory neurons and periodically reactivates from latency to cause recurrent disease. Recent findings implicate HSV-specific CD8(+) T cells in immune surveillance of HSV-1 latently infected sensory neurons in trigeminal ganglia (TG) and inhibition of HSV-1 reactivation from latency. This review summarizes recent findings regarding the characteristics of the TG-resident CD8(+) T cell population and certain unique obstacles that might complicate the development of therapeutic vaccines.
疱疹病毒的一个显著特征是其导致复发性疾病的能力。单纯疱疹病毒 1 型（HSV-1）疾病的复发并非源于来自外部来源的再感染，而是源自潜伏在感觉神经元中并定期从潜伏状态中重新激活导致复发性疾病的病毒的激活。最近的发现表明，HSV 特异性 CD8(+)T 细胞参与了对三叉神经节（TG）中潜伏感染的 HSV-1 感觉神经元的免疫监视，并抑制了 HSV-1 从潜伏状态中的重新激活。这篇综述总结了关于 TG 驻留 CD8(+)T 细胞群体的特征以及某些可能使治疗性疫苗的开发复杂化的独特障碍的最新发现。
