Department of Oncology, Xiangya Hospital, Central South University, Changsha, China.
Planta Med. 2012 Feb;78(3):237-43. doi: 10.1055/s-0031-1280366. Epub 2011 Dec 12.
Shaoyao-Gancao-Tang (SGT) is a traditional Chinese prescription containing Radix Paeoniae alba and Radix Glycyrrhizae and is commonly used to relieve pains. Albiflorin and paeoniflorin are the main effective compounds of Radix Paeoniae alba, and the pharmacokinetic differences of the two compounds in rats after oral administration of SGT and single herb Paeony decoction were studied. At different time points (5, 10, 15, 20, 30, 45, 60, 90, 120, 180, 240, 360, and 540 min) after administration, plasma concentrations of albiflorin and paeoniflorin were determined using a simple and reliable UPLC method, and main pharmacokinetic parameters were evaluated. It was found that there were significant differences (p < 0.05 or p < 0.01) between the two groups. The results indicated that some components in the other ingredient herb of SGT (Radix Glycyrrhizae) had a pharmacokinetic interaction with albiflorin and paeoniflorin and hence reduced their systematic exposure level.
芍药甘草汤（SGT）是一种含有白芍和甘草的传统中药方剂，常用于缓解疼痛。白芍苷和芍药苷是白芍的主要有效成分，研究了 SGT 和单味芍药汤灌胃给药后大鼠体内这两种化合物的药代动力学差异。在给药后不同时间点（5、10、15、20、30、45、60、90、120、180、240、360 和 540 分钟），采用简单可靠的 UPLC 法测定血浆中白芍苷和芍药苷的浓度，并评价主要药代动力学参数。结果表明，两组间存在显著差异（p<0.05 或 p<0.01）。结果表明，SGT 中其他成分甘草（甘草）的一些成分与白芍苷和芍药苷存在药代动力学相互作用，从而降低了它们的系统暴露水平。
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