Stem Cells. 2012 Jan;30(1):2-9. doi: 10.1002/stem.1007.
To celebrate 30 years of peer-reviewed publication of cutting edge stem cell research in Stem Cells, the first journal devoted to this promising field, we pause to review how far we have come in the three-decade lifetime of the Journal. To do this, we will present our views of the 10 most significant developments that have advanced stem cell biology where it is today. With the increasing rate of new data, it is natural that the bulk of these developments would have occurred in recent years, but we must not think that stem cell biology is a young science. The idea of a stem cell has actually been around for quite a long time having appeared in the scientific literature as early as 1868 with Haeckels' concept of a stamzelle as an uncommitted or undifferentiated cell responsible for producing many types of new cells to repair the body [Naturliche Schopfungsgeschichte, 1868; Berlin: Georg Reimer] but it took many years to obtain hard evidence in support of this theory. Not until the work of James Till and Ernest McCulloch in the 1960s did we have proof of the existence of stem cells and until the derivation of embryonal carcinoma cells in the 1960s-1970s and the first embryonic stem cell in 1981, such adult or tissue-specific stem cells were the only known class. The first issue of Stem Cells was published in 1981; no small wonder that most of its papers were devoted to hematopoietic progenitors. More recently, induced pluripotent stem cells (iPSCs) have been developed, and this is proving to be a fertile area of investigation as shown by the volume of publications appearing not only in Stem Cells but also in other journals over the last 5 years. The reader will note that many of the articles in this special issue are concerned with iPSC; however, this reflects the current surge of interest in the topic rather than any deliberate attempt to ignore other areas of stem cell investigation.
为了庆祝《干细胞》杂志创刊 30 周年，该杂志是第一本专注于这一极有前途领域的期刊，对前沿的干细胞研究进行同行评审。在这 30 年的期刊生涯中，我们回顾一下该领域取得的进展。为此，我们将提出我们对推进干细胞生物学发展的 10 项最重要进展的看法。随着新数据的不断增加，这些进展大多发生在近几年是很自然的，但我们绝不能认为干细胞生物学是一门年轻的科学。事实上，干细胞的概念已经存在了相当长的一段时间，可以追溯到 1868 年，海克尔（Haeckels）的概念提出了一种未分化的细胞——生殖细胞（stamzelle），作为一种未分化或未分化的细胞，负责产生多种新细胞来修复身体[《自然发生的历史》，1868 年；柏林：格奥尔格·雷默]，但直到几十年后才获得支持这一理论的有力证据。直到 20 世纪 60 年代，詹姆斯·蒂尔（James Till）和欧内斯特·麦卡洛克（Ernest McCulloch）的工作才证明了干细胞的存在，直到 20 世纪 60 年代至 70 年代胚胎癌细胞的衍生和 1981 年第一个胚胎干细胞的出现，这种成体或组织特异性干细胞才是唯一已知的细胞。《干细胞》杂志的第一期于 1981 年出版；毫不奇怪，其大多数论文都致力于造血祖细胞。最近，诱导多能干细胞（iPSCs）已经开发出来，正如过去 5 年来不仅在《干细胞》杂志上而且在其他杂志上发表的大量出版物所显示的那样，这是一个富有成效的研究领域。读者会注意到，本期特刊中的许多文章都涉及 iPSC；然而，这反映了人们对这一主题的兴趣激增，而不是故意试图忽视干细胞研究的其他领域。
