Lukinmaa P L, Hietanen J, Anttinen J, Ahonen P
Department of Dental Radiology/Oral Pathology, University of Helsinki, Finland.
Oral Surg Oral Med Oral Pathol. 1990 Sep;70(3):313-7. doi: 10.1016/0030-4220(90)90147-k.
Defective odontogenesis and/or retarded eruption of teeth can be associated with histologic features akin to odontogenic fibroma in the dental follicles. Unerupted mandibular premolar and molar teeth of a 24-year-old man were surgically exposed, yet the teeth failed to erupt. About a year and a half later, radiographs indicated further enlargement of the follicle of the premolar, and both teeth were subsequently surgically removed. Histologically, the follicles were composed of mature collagenous tissue among which epithelial islands and numerous clusters of calcified bodies were present. Indirect immunofluorescence showed positive staining for type I and type III collagen, which exhibited a sparse distribution, but not for the aminoterminal propeptide of type III procollagen. The hamartomatous nature of the lesions is discussed with emphasis on their histologic resemblance to the WHO type of odontogenic fibroma.
牙发育不全和/或牙齿萌出迟缓可能与牙囊内类似于牙源性纤维瘤的组织学特征有关。一名24岁男性的下颌前磨牙和磨牙未萌出，手术暴露后仍未能萌出。大约一年半后，X线片显示前磨牙的牙囊进一步增大，随后两颗牙齿均被手术拔除。组织学上，牙囊由成熟的胶原组织组成，其中可见上皮岛和大量钙化小体簇。间接免疫荧光显示I型和III型胶原呈阳性染色，分布稀疏，但III型前胶原氨基端前肽染色阴性。讨论了病变的错构瘤性质，重点强调了其与世界卫生组织型牙源性纤维瘤的组织学相似性。
