Karseladze A I
Arkh Patol. 2011 Jul-Aug;73(4):29-33.
The analysis of possible morphogenesis of the different structures in human yolk sac tumor has been considered. The author has supposed that features of blood vessel microarchitecture formation and perpetual differentiation of tumor cells or theirs functional modification play a crucial role in the morphogenesis of YST. The immunohistochemical investigation of some stem cells markers has showed the necessity of accounting of their distribution pattern in various cellular structures for the differential diagnosis of morphogenetical steps of YST. The growth of tumor cells differentiation rate correlates with increasing of stem cells markers expression as well c-kit > OCT4 > CD30 > PLAP.
对人类卵黄囊瘤不同结构可能的形态发生进行了分析。作者推测，血管微结构形成的特征以及肿瘤细胞的持续分化或其功能修饰在卵黄囊瘤的形态发生中起关键作用。对一些干细胞标志物的免疫组织化学研究表明，在卵黄囊瘤形态发生步骤的鉴别诊断中，有必要考虑它们在各种细胞结构中的分布模式。肿瘤细胞分化率的增长与干细胞标志物表达的增加相关，即c-kit>OCT4>CD30>PLAP。
