[The influence of C57B1/6J mice immunization by oxidized low-density lipoprotein on the intensity of atherosclerotic changes].

ApoE knockout C57B1/6J mice fed Western type diet were immunized by MDA-modified human LDL. After 8 weeks in 50% immunized mice the atherosclerotic lesions in aorta was absent whereas both in control group and in 50% immunized mice the region of atherosclerotic lesions was in average 6,6%. A positive correlation between area of lesions and level of antilipoprotein antibodies IgG2b was founded.