Badalato Gina M, Wosnitzer Matthew S, Truesdale Matthew D, Sandri Marco, Ko Woo Jin, Landman Jaime, Badani Ketan K
Department of Urology, Columbia University Medical Center, New York, New York 10032, USA.
Can J Urol. 2011 Dec;18(6):6031-6.
Bioimpedance spectroscopy (BIS) is a novel, precise quantification of body composition (BC) using low electrical currents through tissue. Accurate BC quantification may better predict postoperative outcomes. We compared BIS-BC and body mass index (BMI) for correlation with post-surgical outcomes in robotic assisted radical prostatectomy (RARP) patients.
Preoperative BIS-BC and BMI analyses were conducted on men with biopsy-proven prostate cancer undergoing RARP. Height, weight, percentage and fat mass (PFM, FM), percentage and fat-free mass (PFFM, FFM), percentage and total body water (PTBW, TBW), and percentage and intracellular/extracellular water (PICW, PECW, ICW, ECW) were obtained using the ImpediMed SFB7 Device (San Diego, CA, USA). Preoperative PSA, biopsy and pathologic Gleason scores, prostate volume, percentage tumor volume, margin status, operative time, estimated blood loss (EBL) and pathologic stage were recorded. Spearman's rank correlation was estimated to evaluate the association between BIS-BC results, BMI, and post-surgical outcomes.
Between April 2009 and August 2010, 63 men had been enrolled in this ongoing study. Fourteen were of normal weight (18.5 kg/m2-24.9 kg/m2), 33 were overweight (25 kg/m2-29.9 kg/m2) and 16 were obese (BMI ≥ 30 kg/m2). Mean age was 60.7 years, mean preoperative PSA was 7.4 ng/mL, and median Gleason was 7. BMI correlated with FFM (p = 0.002), FM (p = 0.01), and PTBW (p = 0.02). FM correlated with preoperative PSA (p = 0.01). PFFM (p = 0.03), PFM (p = 0.03) and PTBW (p = 0.04) correlated with % tumor volume. ICW (p = 0.01) and TBW (p = 0.009) correlated with EBL. BMI (p = 0.04), PECW (p = 0.04), FM (p = 0.05), and PICW (p = 0.03) correlated with pathologic tumor stage.
BMI correlates with BIS-BC FFM, FM and PTBW. PFFM, PFM and PTBW correlated with % tumor volume. ICW and TBW correlated with EBL. BMI, PECW, FM, and PICW correlated with pathologic tumor stage. BIS-BC metrics may be helpful in predicting post-RARP outcomes. Further study is required to validate these predictions.
生物电阻抗光谱法（BIS）是一种通过向组织施加低电流来精确量化身体成分（BC）的新方法。准确的身体成分量化可能能更好地预测术后结果。我们比较了BIS-BC和体重指数（BMI）与机器人辅助根治性前列腺切除术（RARP）患者术后结果的相关性。
对经活检证实患有前列腺癌且接受RARP的男性进行术前BIS-BC和BMI分析。使用美国加利福尼亚州圣地亚哥市的ImpediMed SFB7设备获取身高、体重、脂肪百分比和脂肪量（PFM、FM）、去脂体重百分比和去脂体重（PFFM、FFM）、总体水百分比和总体水（PTBW、TBW）以及细胞内/外水百分比（PICW、PECW、ICW、ECW）。记录术前前列腺特异性抗原（PSA）、活检和病理Gleason评分、前列腺体积、肿瘤体积百分比、切缘状态、手术时间、估计失血量（EBL）和病理分期。采用Spearman等级相关性分析来评估BIS-BC结果、BMI与术后结果之间的关联。
在2009年4月至2010年8月期间，63名男性纳入了这项正在进行的研究。14人体重正常（18.5kg/m² - 24.9kg/m²），33人超重（25kg/m² - 29.9kg/m²），16人肥胖（BMI≥30kg/m²）。平均年龄为60.7岁，术前平均PSA为7.4ng/mL，Gleason评分中位数为7。BMI与FFM（p = 0.002）、FM（p = 0.01）和PTBW（p = 0.02）相关。FM与术前PSA相关（p = 0.01）。PFFM（p = 0.03）、PFM（p = 0.03）和PTBW（p = 0.04）与肿瘤体积百分比相关。ICW（p = 0.01）和TBW（p = 0.009）与EBL相关。BMI（p = 0.04）、PECW（p = 0.04）、FM（p = 0.05）和PICW（p = 0.03）与病理肿瘤分期相关。
BMI与BIS-BC的FFM、FM和PTBW相关。PFFM、PFM和PTBW与肿瘤体积百分比相关。ICW和TBW与EBL相关。BMI、PECW、FM和PICW与病理肿瘤分期相关。BIS-BC指标可能有助于预测RARP术后结果。需要进一步研究来验证这些预测。
