年龄、性别及硫嘌呤甲基转移酶（TPMT）基因单倍型对急性淋巴细胞白血病患儿6-巯基嘌呤毒性的影响 - Suppr

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Influence of age, sex, and haplotypes of thiopurine methyltransferase (TPMT) gene on 6- mercaptopurine toxicity in children with acute lymphoblastic leukemia.

作者信息

Uppugunduri Chakradhara Rao S, Ansari Marc

出版信息

Eur J Clin Pharmacol. 2012 May;68(5):887-8; author reply 885-6. doi: 10.1007/s00228-011-1185-2. Epub 2011 Dec 14.

DOI:10.1007/s00228-011-1185-2

PMID:22166935

Abstract

摘要

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Influence of age, sex, and haplotypes of thiopurine methyltransferase (TPMT) gene on 6- mercaptopurine toxicity in children with acute lymphoblastic leukemia.年龄、性别及硫嘌呤甲基转移酶（TPMT）基因单倍型对急性淋巴细胞白血病患儿6-巯基嘌呤毒性的影响

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本文引用的文献

Eur J Clin Pharmacol. 2012 Apr;68(4):379-87. doi: 10.1007/s00228-011-1133-1. Epub 2011 Oct 19.

Thiopurine S-methyltransferase pharmacogenetics in a large-scale healthy Italian-Caucasian population: differences in enzyme activity.大规模意大利-高加索健康人群中的硫嘌呤 S-甲基转移酶药物遗传学：酶活性的差异。

Pharmacogenomics. 2009 Nov;10(11):1753-65. doi: 10.2217/pgs.09.103.

Thiopurine S-methyltransferase (TPMT) pharmacogenetics: three new mutations and haplotype analysis in the Estonian population.硫嘌呤甲基转移酶（TPMT）药物遗传学：爱沙尼亚人群中的三个新突变及单倍型分析

Clin Chem Lab Med. 2008;46(7):974-9. doi: 10.1515/CCLM.2008.187.

Explaining TPMT genotype/phenotype discrepancy by haplotyping of TPMT*3A and identification of a novel sequence variant, TPMT*23.通过对TPMT*3A进行单倍型分析并鉴定一种新的序列变异体TPMT*23来解释TPMT基因型/表型差异

Pharmacogenet Genomics. 2007 Oct;17(10):891-5. doi: 10.1097/FPC.0b013e3282ef642b.

Using HapMap tools in pharmacogenomic discovery: the thiopurine methyltransferase polymorphism.在药物基因组学发现中使用HapMap工具：硫嘌呤甲基转移酶多态性

Clin Pharmacol Ther. 2007 May;81(5):729-34. doi: 10.1038/sj.clpt.6100135. Epub 2007 Feb 28.

Treatment of acute lymphoblastic leukaemia in countries with limited resources; lessons from use of a single protocol in India over a twenty year period [corrected].资源有限国家的急性淋巴细胞白血病治疗；印度20年间使用单一方案的经验教训[已修正]

Eur J Cancer. 2005 Jul;41(11):1570-83. doi: 10.1016/j.ejca.2004.11.004. Epub 2005 Jan 5.

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