Collyn d'Hooghe M, Fenaux P, Lantoine D, Loucheux-Lefebvre M, Kerckaert J P
Unité 124 INSERM, Institut de Recherches sur le Cancer, Lille, France.
Nouv Rev Fr Hematol (1978). 1990;32(3):175-7.
We studied the expression of IL 6 gene in 49 patients, including 21 chronic myelomonocytic leukemias (CML), 9 other myelodysplastic syndromes (MDS), 18 acute myeloid leukemias (11 M2 or M3 and 7 M4 or M5) and 1 case of acute biphenotypic lymphoid monocytic leukemia. IL 6 was found expressed only in the latter patient and in one patient with M5 acute myeloid leukemia. DNA analysis by Southern blot revealed no rearrangement in these 2 patients and in 10 of the other patients who showed no IL 6 expression. These results do not support an autocrine role for IL 6 in CMML or in other MDS. In acute myeloid leukemias, if expressed by leukemic cells, IL 6 seems to be restricted to cases with a monocytic component, although the number of patients was too small to draw any definite conclusion.
我们研究了49例患者白细胞介素6（IL 6）基因的表达情况，其中包括21例慢性粒单核细胞白血病（CML）、9例其他骨髓增生异常综合征（MDS）、18例急性髓系白血病（11例M2或M3型以及7例M4或M5型）和1例急性双表型淋巴单核细胞白血病。结果发现，仅在最后1例患者以及1例M5型急性髓系白血病患者中检测到IL 6表达。通过Southern印迹法进行的DNA分析显示，这2例患者以及另外10例未表达IL 6的患者均未出现重排。这些结果不支持IL 6在CMML或其他MDS中发挥自分泌作用。在急性髓系白血病中，如果白血病细胞表达IL 6，似乎仅限于有单核细胞成分的病例，不过由于患者数量过少，无法得出任何确切结论。
