Geburek F, Stadler P
Fachtierarzt für Pferde, Stiftung Tierärztliche Hochschule Hannover, Klinik für Pferde, Bünteweg 9, 30559 Hannover.
Tierarztl Prax Ausg G Grosstiere Nutztiere. 2011;39(6):373-83.
Conventional treatments of equine tendon injuries lead to an unsatisfactory healing process that usually results in a relatively high recurrence rate. Therefore, in recent years so-called regenerative therapeutics were studied scientifically in vitro and in laboratory animals. These include substances that ideally lead to the formation of replacement tissue, which in contrast to the low quality scar, has similar functional properties as the original intact tendon. Currently, a plethora of different substrates is either commercially available or can be produced in practice with the help of kits. The current knowledge on the production and the regenerative potential of nucleated cells like stem cells from bone marrow and fat tissue, of the blood products PRP (platelet rich plasma), ACP (autologous conditioned plasma), ACS (autologous conditioned serum) and of the scaffold substance UBM (urinary bladder matrix) are presented. Finally, the potential of some growth factors and of gene therapy is considered. Currently, it is assumed that the regeneration of tendon tissue is promoted by a complex interaction of scaffolds, growth factors and cells. At present, only very few studies are available which allow a comparison between these substances. Studies on the effect of regenerative substrates on tendons in live horses are presented elsewhere.
马肌腱损伤的传统治疗方法导致愈合过程不尽人意，通常复发率相对较高。因此，近年来所谓的再生疗法在体外和实验动物身上进行了科学研究。这些疗法包括理想情况下能促使替代组织形成的物质，与质量较差的疤痕不同，这种替代组织具有与原始完整肌腱相似的功能特性。目前，大量不同的基质要么已商业化供应，要么可以借助试剂盒在实践中生产出来。本文介绍了关于有核细胞（如来自骨髓和脂肪组织的干细胞）、血液制品富血小板血浆（PRP）、自体条件血浆（ACP）、自体条件血清（ACS）以及支架物质膀胱基质（UBM）的生产和再生潜力的现有知识。最后，探讨了一些生长因子和基因治疗的潜力。目前认为，肌腱组织的再生是由支架、生长因子和细胞之间的复杂相互作用所促进的。目前，仅有极少数研究能够对这些物质进行比较。关于再生基质对活马肌腱影响的研究在其他地方有所介绍。
