Zhang Quan, Wang Cui, Zhang Xiaofeng, Jin Daqing, Huang Changjiang, Zhao Meirong
Research Centre of Environmental Science, Zhejiang University of Technology, Hangzhou 310032, People's Republic of China.
J Environ Monit. 2012 Feb;14(2):465-72. doi: 10.1039/c1em10687b. Epub 2011 Dec 13.
Chiral pesticides are ubiquitous in the aquatic environment, and their enantioselectivities in aquatic toxicity are known to be complicated. The difference in enantioselective effects between enantiomers may sometimes differ by approximately 100-fold or more, which makes it important to incorporate enantioselective effects into the risk assessment of chiral pesticides. In this paper, we reviewed relevant work on the aquatic toxicity of chiral pesticides with an emphasis on the enantioselective aquatic toxicity under both chronic and acute exposure conditions. We provided a personal account of the importance of studies on molecular mechanisms of developmental toxicity and specific endpoints such as vitellogenin, yolk sac edema and pericardial edema in future research. Given the widespread use of chiral pesticides, we suggest that a more comprehensive understanding of the significance of enantioselective aquatic toxicity will be very helpful in improving risk assessment and regulation of chiral pesticides.
手性农药在水生环境中普遍存在，并且已知它们在水生毒性方面的对映体选择性很复杂。对映体之间对映选择性效应的差异有时可能相差约100倍或更多，这使得将对映选择性效应纳入手性农药的风险评估中变得很重要。在本文中，我们综述了关于手性农药水生毒性的相关工作，重点关注慢性和急性暴露条件下的对映选择性水生毒性。我们个人阐述了发育毒性分子机制研究以及未来研究中诸如卵黄蛋白原、卵黄囊水肿和心包水肿等特定终点的重要性。鉴于手性农药的广泛使用，我们建议更全面地了解对映选择性水生毒性的意义将非常有助于改进手性农药的风险评估和监管。
