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本文引用的文献

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Default-mode network connectivity and white matter burden in late-life depression.老年期抑郁症中的默认模式网络连通性与白质负荷。
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Altered cerebral blood flow patterns associated with pathologic worry in the elderly.老年人病理性担忧相关的脑血流模式改变。
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Research domain criteria (RDoC): toward a new classification framework for research on mental disorders.研究领域标准（RDoC）：迈向精神障碍研究的新分类框架
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Arterial spin labeling blood flow MRI: its role in the early characterization of Alzheimer's disease.动脉自旋标记血流 MRI：在阿尔茨海默病早期特征化中的作用。
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'Bipolar disorder' in the elderly: what's in a name?老年人的“双相情感障碍”：名称有何意义？
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Functional connectivity in late-life depression using resting-state functional magnetic resonance imaging.使用静息态功能磁共振成像技术研究老年期抑郁症的功能连接
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Neuroanatomical and neuropsychological features of euthymic patients with bipolar disorder.双相情感障碍患者缓解期的神经解剖学和神经心理学特征。
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fMRI activation in late-life anxious depression: a potential biomarker.老年焦虑性抑郁症的 fMRI 激活：一种潜在的生物标志物。
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老年期情绪障碍的磁共振成像研究。

MRI studies in late-life mood disorders.

作者信息

Andreescu Carmen, Aizenstein Howard

机构信息

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

出版信息

Curr Top Behav Neurosci. 2012;11:269-87. doi: 10.1007/7854_2011_175.

DOI:10.1007/7854_2011_175
PMID:22167336
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3733498/
Abstract

There are well-established patterns of structural brain changes associated with aging. The change in brain volume with age and with the diseases of aging presents a particular challenge for MRI studies in the elderly. Structural MRI is important for studies in normal aging, late-life depression, dementia, Alzheimer disease and other cognitive disorders to examine how age-associated changes in neuroanatomy are associated with specific age-related changes in brain function. Functional MRI has been a major advance for the fields of cognitive and affective neuroscience by allowing investigators to test theories of the underlying neural pathways controlling cognitive and emotional processes. In this chapter, we will review the contribution of MRI studies to late-life mood and anxiety disorders: major depression, bipolar disorder and anxiety disorders in late-life.

摘要

与衰老相关的大脑结构变化模式已得到充分证实。随着年龄增长以及衰老相关疾病的出现，脑容量的变化给老年人群的磁共振成像（MRI）研究带来了特殊挑战。结构MRI对于正常衰老、晚年抑郁症、痴呆症、阿尔茨海默病及其他认知障碍的研究至关重要，可用于检查神经解剖结构中与年龄相关的变化如何与大脑功能中特定的年龄相关变化相关联。功能MRI通过让研究人员能够测试控制认知和情感过程的潜在神经通路理论，在认知和情感神经科学领域取得了重大进展。在本章中，我们将回顾MRI研究对晚年情绪和焦虑障碍（包括重度抑郁症、双相情感障碍和晚年焦虑症）的贡献。