Kobe Tokushukai Hospital, Kobe, Japan.
Int J Hematol. 2012 Feb;95(2):198-203. doi: 10.1007/s12185-011-0978-5. Epub 2011 Dec 14.
Dysregulated overproduction of interleukin-6 (IL-6) from activated B cells in affected lymph nodes has been implicated in the pathogenesis of multicentric Castleman's disease (MCD), a rare lymphoproliferative disorder accompanied by systemic manifestations. We here report the case of a 32-year-old female presenting with MCD associated with a dermoid cyst in the pelvic cavity. The co-occurrence of MCD and dermoid cyst has not been reported before. Immunohistochemical analysis of the tissue sections showed IL-6 production in CD68-positive macrophage cells, which had infiltrated the dermoid cyst. Removal of the cyst resulted in partial improvement in systemic symptoms accompanied by a decrease in serum IL-6, while complete improvement was obtained by treatment with an anti-IL-6 receptor antibody following resection of the dermoid cyst. To the best of our knowledge, this is the first study to provide evidence of IL-6 production by CD68(+) cells in a dermoid cyst involved in MCD.
活化的淋巴结 B 细胞中白细胞介素-6（IL-6）的失调过度产生，与多中心 Castleman 病（MCD）的发病机制有关，MCD 是一种罕见的淋巴增生性疾病，伴有全身表现。我们在此报告一例 32 岁女性，患有与盆腔皮样囊肿相关的 MCD。MCD 与皮样囊肿同时发生以前未有报道。组织切片的免疫组织化学分析显示，CD68 阳性巨噬细胞产生了 IL-6，这些巨噬细胞已经浸润了皮样囊肿。囊肿切除后，全身症状部分改善，同时血清 IL-6 下降，而皮样囊肿切除后，使用抗 IL-6 受体抗体治疗则获得完全改善。据我们所知，这是第一项提供证据表明在涉及 MCD 的皮样囊肿中 CD68(+)细胞产生 IL-6 的研究。
