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二尖瓣修复术在肥厚性梗阻性心肌病患者中的应用未得到充分利用。

Mitral valve repair is underused in patients with hypertrophic obstructive cardiomyopathy.

作者信息

Vassileva Christina M, Boley Theresa, Markwell Stephen, Hazelrigg Stephen

机构信息

Division of Cardiothoracic Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62794-9638, USA.

出版信息

Heart Surg Forum. 2011 Dec;14(6):E376-9. doi: 10.1532/HSF98.20111067.

DOI:10.1532/HSF98.20111067
PMID:22167765
Abstract

BACKGROUND

The optimal surgical approach for patients with hypertrophic obstructive cardiomyopathy (HOCM) with concomitant mitral valve (MV) regurgitation has remained controversial. The purpose of this study was to use the largest all-payer database in the United States to examine the strategy most commonly used for the correction of mitral valve pathology in the setting of HOCM.

METHODS

The Nationwide Inpatient Sample (NIS) database was searched from 2005 to 2008 to identify patients with a diagnosis of HOCM (ICD-9-CM code 425.1) who underwent MV repair (ICD-9-CM code 35.12) or replacement (ICD-9-CM codes 35.23 and 35.24). HOCM patients who underwent MV repair and those who underwent MV replacement were compared with respect to baseline characteristics, repair rates, hospital mortality, and length of stay (LOS).

RESULTS

MV repair was performed in 17.2% of cases (219/1255). Repair rates did not show a significantly increasing trend over time (P = .1419). The median LOS was significantly longer for replacement than for repair (11 days versus 7 days, P = .0001). The mortality rate for patients who underwent repair was 0.00%, compared with 11.18% for those who underwent replacement (P < .05).

CONCLUSIONS

The majority of patients with a HOCM diagnosis underwent MV replacement for the correction of MV pathology. Referral to centers with special expertise in treating patients with HOCM may positively affect the operative outcomes of this patient subset.

摘要

背景

对于患有肥厚性梗阻性心肌病(HOCM)并伴有二尖瓣(MV)反流的患者,最佳手术方式一直存在争议。本研究旨在利用美国最大的全付费者数据库,探讨在HOCM情况下最常用于纠正二尖瓣病变的策略。

方法

检索2005年至2008年的全国住院患者样本(NIS)数据库,以识别诊断为HOCM(国际疾病分类第九版临床修订本代码425.1)且接受二尖瓣修复(国际疾病分类第九版临床修订本代码35.12)或置换(国际疾病分类第九版临床修订本代码35.23和35.24)的患者。比较接受二尖瓣修复的HOCM患者和接受二尖瓣置换的患者的基线特征、修复率、医院死亡率和住院时间(LOS)。

结果

17.2%的病例(219/1255)进行了二尖瓣修复。修复率未显示出随时间显著增加的趋势(P = 0.1419)。置换后的中位住院时间显著长于修复(11天对7天,P = 0.0001)。接受修复的患者死亡率为0.00%,而接受置换的患者死亡率为11.18%(P < 0.05)。

结论

大多数诊断为HOCM的患者接受二尖瓣置换以纠正二尖瓣病变。转诊至在治疗HOCM患者方面具有专业专长的中心可能会对这一患者亚组的手术结果产生积极影响。

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