Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, United States.
Cell Immunol. 2012;272(2):117-23. doi: 10.1016/j.cellimm.2011.11.002. Epub 2011 Nov 25.
Within lymphopenic recipients, naïve T cells undergo proliferation that is induced by homeostatic mechanisms. Earlier studies have demonstrated that commensal antigens play a key role in inducing the proliferation. However, a relative contribution of endogenous self antigens in this process has not been formally investigated. In this study, we utilized a pharmacologic inhibitor that blocks T cell egress from the lymphoid tissues, antibiotics, and germ-free animals to examine the role of commensal and self antigens. The results suggest that T cell proliferation under lymphopenic conditions is a heterogeneous process triggered by both exogenous commensal and endogenous self antigens.
在淋巴细胞减少的受者中，幼稚 T 细胞通过自身平衡机制诱导的增殖。早期的研究表明，共生抗原在诱导增殖中起关键作用。然而，内源性自身抗原在这个过程中的相对贡献尚未得到正式研究。在这项研究中，我们利用一种药理学抑制剂来阻断 T 细胞从淋巴组织中流出，抗生素和无菌动物来研究共生抗原和自身抗原的作用。结果表明，淋巴细胞减少条件下的 T 细胞增殖是一个由外源性共生抗原和内源性自身抗原共同触发的异质过程。
