Department of Ophthalmology, Ankara University Faculty of Medicine, Ankara, Turkey.
Eye Contact Lens. 2012 Sep;38(5):341-4. doi: 10.1097/ICL.0b013e318237d195.
We report three cases of corneal melanoma: two without conjunctival primary acquired melanosis or melanoma and one with a history of conjunctival melanoma.
Report of 3 cases with corneal melanoma and literature review.
Medical records of three patients with the diagnosis of corneal melanoma were reviewed. Total excisional biopsy with corneal epitheliectomy using 20% ethanol was performed. Postoperative topical chemotherapy with 0.04% mitomycin-C was used for 4 weeks as adjunctive therapy. The follow-up ranged from 13 months to 7 years. Each of the two patients experienced two recurrences. One was treated in a fashion similar to that of the initial tumor, and the other was treated by enucleation. None of the patients developed regional or distant metastasis.
Malignant melanoma can rarely occur on the cornea with no contiguous conjunctival component. Eye-conserving treatment should be attempted first. Recurrences may occur, and a close follow-up is necessary.
我们报告三例角膜黑色素瘤病例：两例无结膜原发性获得性黑色素沉着或黑色素瘤，一例有结膜黑色素瘤病史。
报告三例角膜黑色素瘤病例，并进行文献复习。
回顾了三例诊断为角膜黑色素瘤患者的病历。采用 20%乙醇行全切除性活检联合角膜上皮切除术。术后行 0.04%丝裂霉素 C 局部化疗 4 周作为辅助治疗。随访时间为 13 个月至 7 年。两名患者各复发两次。一次采用与初次肿瘤相似的方式治疗，另一次采用眼球摘除术治疗。无患者发生局部或远处转移。
无毗邻结膜成分的角膜也可罕见发生恶性黑色素瘤。应首先尝试保留眼球的治疗。可能会复发，需要密切随访。
