Wolfram G, Eckart J, Walther B, Zöllner N
JPEN J Parenter Enteral Nutr. 1978 Nov;2(5):634-9. doi: 10.1177/014860717800200503.
Twenty patients, after major injuries or elective abdominal surgery, were studied with respect to essential fatty acids in total serum and lipoprotein fractions. The regimen of total parenteral nutrition was altered in its content of energy, carbohydrates or fat. In all patients the linoleic acid levels decreased and the 20:3/20:4 ratio increased. Serum low density lipoproteins developed remarkable alterations of the biochemical composition and of morphology by electronmicroscopy. The degree of these alterations depended on the kind of illness, the amount of carbohydrates infused, special hormonal situation due to surgery and linoleic acid supply. As a consequence of these results, the supply of a sufficient amount of linoleic acid should be considered in every case of total parenteral nutrition.
对20名遭受严重创伤或接受择期腹部手术的患者进行了全血清和脂蛋白组分中必需脂肪酸的研究。全胃肠外营养方案在能量、碳水化合物或脂肪含量方面进行了调整。所有患者的亚油酸水平均下降，20:3/20:4比值升高。血清低密度脂蛋白在生化组成和电子显微镜下的形态上出现了显著改变。这些改变的程度取决于疾病类型、输注碳水化合物的量、手术导致的特殊激素状况以及亚油酸供应情况。基于这些结果，在每例全胃肠外营养病例中都应考虑提供足够量的亚油酸。
