Conway G S, Jacobs H S
Cobbold Laboratories, Middlesex Hospital, London, UK.
Postgrad Med J. 1990 Jul;66(777):536-8. doi: 10.1136/pgmj.66.777.536.
Fasting and stimulated insulin concentrations in four patients with acanthosis nigricans and polycystic ovary syndrome were compared with four patients, matched for weight and ovarian morphology, without acanthosis. The median fasting serum insulin concentrations were 114.2 and 25.1 mU/l in the respective groups (P = 0.02). One additional patient was investigated before and after an 18% increase in weight which resulted in a 170% increase in fasting insulin concentrations and the development of acanthosis nigricans. These observations suggest that there is variation between individuals in the degree of obesity that results in the development of acanthosis and that obese patients with this skin condition represent the severe end of the spectrum of the polycystic ovary syndrome.
对4例黑棘皮病合并多囊卵巢综合征患者与4例体重和卵巢形态匹配但无黑棘皮病的患者的空腹和刺激后胰岛素浓度进行了比较。两组的空腹血清胰岛素浓度中位数分别为114.2和25.1 mU/l（P = 0.02）。另外一名患者在体重增加18%前后接受了调查，体重增加导致空腹胰岛素浓度增加170%并出现黑棘皮病。这些观察结果表明，导致黑棘皮病发生的肥胖程度在个体之间存在差异，患有这种皮肤疾病的肥胖患者代表了多囊卵巢综合征谱系的严重一端。
