Wortsman J, Matsuoka L Y, Kupchella C E, Gavin J R, Dietrich J G
Arch Intern Med. 1983 Jun;143(6):1145-8.
Skin biopsy specimens of acanthosis nigricans (AN) lesions were obtained from seven women with the polycystic ovary (PCO) syndrome and insulin resistance (IR). All the patients had normal thyroid function test results and fasting hyperinsulinemia with an exaggerated insulin response to oral glucose. Acanthosis nigricans lesions exhibited prominent deposits of glycosaminoglycan (GAG) consisting mostly of hyaluronic acid in the papillary dermis. Normal amounts of GAGs were found in control biopsy specimens obtained from areas of the skin not involved by AN and from skin of the nape of the neck or axillae in three normal women. These studies demonstrate that GAG deposition is a regular component of AN skin in patients with PCO and IR. The cause of these infiltrates remains to be determined.
从7名患有多囊卵巢（PCO）综合征和胰岛素抵抗（IR）的女性身上获取了黑棘皮病（AN）病变的皮肤活检标本。所有患者甲状腺功能测试结果均正常，存在空腹高胰岛素血症，且口服葡萄糖后胰岛素反应增强。黑棘皮病病变在乳头真皮层表现出大量糖胺聚糖（GAG）沉积，主要由透明质酸组成。在从未受AN影响的皮肤区域以及3名正常女性的颈后或腋窝皮肤获取的对照活检标本中发现了正常量的GAG。这些研究表明，GAG沉积是PCO和IR患者AN皮肤的一个常见组成部分。这些浸润的原因仍有待确定。
