甲芬那酸诱发的老年甲状腺功能减退女性中性粒细胞减少症和肾衰竭。
Mefenamic acid-induced neutropenia and renal failure in elderly females with hypothyroidism.
作者信息
Handa S I, Freestone S
机构信息
Department of Haematology, Royal Infirmary, Edinburgh, UK.
出版信息
Postgrad Med J. 1990 Jul;66(777):557-9. doi: 10.1136/pgmj.66.777.557.
We report mefenamic acid-induced non-oliguric renal failure and severe neutropenia occurring simultaneously in two elderly females. The neutropenia was due to maturation arrest of the myeloid series in one patient. Both patients were also hypothyroid, but it is not clear whether this was a predisposing factor to the development of these adverse reactions. However, it would seem prudent not to use mefenamic acid in hypothyroid patients until the hypothyroidism has been corrected.
我们报告了两例老年女性同时发生甲芬那酸诱导的非少尿性肾衰竭和严重中性粒细胞减少症。其中一名患者的中性粒细胞减少是由于髓系成熟停滞所致。两名患者均患有甲状腺功能减退症，但尚不清楚这是否是这些不良反应发生的诱发因素。然而，在甲状腺功能减退症得到纠正之前，似乎谨慎的做法是不在甲状腺功能减退患者中使用甲芬那酸。
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