黑匣子发光：信号与信号传递。
The black box illuminated: signals and signaling.
机构信息
Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
出版信息
J Invest Dermatol. 2012 Mar;132(3 Pt 2):811-9. doi: 10.1038/jid.2011.406. Epub 2011 Dec 15.
Abstract
Unraveling the signaling pathways that transmit information from the cell surface to the nucleus has been a major accomplishment of modern cell and molecular biology. The benefit to humans is seen in the multitude of new therapeutics based on the illumination of these pathways. Although considerable insight has been gained in understanding homeostatic and pathological signaling in the epidermis and other skin compartments, the translation into therapy has been lacking. This review will outline advances made in understanding fundamental signaling in several of the most prominent pathways that control cutaneous development, cell-fate decisions, and keratinocyte growth and differentiation with the anticipation that this insight will contribute to new treatments for troubling skin diseases.
摘要
阐明从细胞膜表面到细胞核传递信息的信号通路，是现代细胞和分子生物学的主要成就之一。这些通路的阐明为许多新的治疗方法提供了依据，这使人类受益匪浅。尽管人们在理解表皮和其他皮肤组织中的稳态和病理信号方面已经取得了相当大的进展，但在将这些知识转化为治疗方法方面却一直存在不足。本文综述了在理解几个最主要的调控皮肤发育、细胞命运决定以及角质形成细胞生长和分化的信号通路方面所取得的进展，以期为治疗棘手的皮肤疾病提供新的治疗方法。
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