肝脏脂肪变性的弥散加权 MRI

Diffusion-weighted MRI of fatty liver.

机构信息

Firat University, School of Medicine, Department of Radiology, Turkey.

出版信息

J Magn Reson Imaging. 2012 May;35(5):1108-11. doi: 10.1002/jmri.23519. Epub 2011 Dec 14.

DOI:10.1002/jmri.23519

PMID:22170763

Abstract

PURPOSE

To investigate the effect of fat infiltration on the apparent diffusion coefficient (ADC) of liver, and assess the relationship between ADC and hepatic fat fraction (HFF).

MATERIALS AND METHODS

MRI scans of 120 consecutive patients were included in this retrospective study. Of these, 42 patients were included in the fatty liver group and 78 in the control group. ADC values were measured from a pair of diffusion-weighted (DW) images (b = 0 mm(2) /s and 1000 mm(2) /s). HFFs were measured using T1W GRE dual-echo images. The difference between the ADCs of the two groups was assessed with the t-test. The relationship between HFF and ADC was determined using linear regression analysis and the Pearson correlation coefficient (r).

RESULTS

Mean HFFs were 0.85 ± 2.86 and 13.67 ± 8.62 in the control and fatty liver groups, respectively. The mean ADC of fatty liver group 1.20 ± 0.22 × 10(-3) mm(2) /s was significantly lower than that of the control group 1.32 ± 0.23 × 10(-3) mm(2) /s (P = 0.02). Linear regression analysis revealed an inverse relationship between ADC and HFF (r = -0.39, P < 0.0001).

CONCLUSION

ADC significantly decreases in patients with >5% HFF, and ADC and HFF exhibit an inverse relationship.

摘要

目的

研究脂肪浸润对肝脏表观扩散系数（ADC）的影响，并评估 ADC 与肝脂肪分数（HFF）之间的关系。

材料与方法

本回顾性研究共纳入 120 例连续患者的 MRI 扫描。其中，42 例患者纳入脂肪肝组，78 例患者纳入对照组。从一对扩散加权（DW）图像（b = 0 mm²/s 和 1000 mm²/s）测量 ADC 值。使用 T1W GRE 双回波图像测量 HFF。采用 t 检验评估两组 ADC 值的差异。采用线性回归分析和 Pearson 相关系数（r）确定 HFF 与 ADC 之间的关系。

结果

对照组和脂肪肝组的平均 HFF 分别为 0.85 ± 2.86 和 13.67 ± 8.62。脂肪肝组的平均 ADC 为 1.20 ± 0.22×10(-3)mm²/s，明显低于对照组的 1.32 ± 0.23×10(-3)mm²/s（P = 0.02）。线性回归分析显示 ADC 与 HFF 呈负相关（r = -0.39，P < 0.0001）。