羟丁酸钠与睡眠呼吸暂停：一个临床案例。

Sodium oxybate and sleep apnea: a clinical case.

机构信息

AP-HP Hôpital Raymond Poincaré, Sleep Unit, Physiology Department, Versailles-St Quentin en Yvelines University, France.

出版信息

J Clin Sleep Med. 2011 Dec 15;7(6):667-8. doi: 10.5664/jcsm.1480.

DOI:10.5664/jcsm.1480

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3227715/

Abstract

Sodium oxybate (GHB, Xyrem, Jazz Pharmaceuticals) is used to treat cataplexy in patients with narcolepsy. We report the case of a middle aged, normo-ponderal narcoleptic woman without risk factors who developed reversible sleep apnea and objective sleepiness when treated by sodium oxybate, with an apnea-hypopnea index (AHI) of 19.7 on sodium oxybate and AHI 4.8 without treatment. Despite a subjective improvement in vigilance, mean sleep latency on MWT decreased from 21 minutes to 8 minutes on sodium oxybate.

摘要

羟丁酸钠（GHB，Xyrem，Jazz 制药公司）用于治疗发作性睡病患者的猝倒症。我们报告了一例中年、正常体重的发作性睡病女性患者，无危险因素，在接受羟丁酸钠治疗后出现可逆性睡眠呼吸暂停和客观嗜睡，羟丁酸钠治疗时的呼吸暂停低通气指数（AHI）为 19.7，未治疗时为 4.8。尽管警觉性主观改善，但MWT 的平均睡眠潜伏期从 21 分钟降至羟丁酸钠治疗时的 8 分钟。

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