P&G Beauty & Grooming Research and Development, Sharon Woods Innovation Center, 11511 Reed Hartman Highway, Cincinnati, OH 45241, USA.
Br J Dermatol. 2011 Dec;165 Suppl 3:24-30. doi: 10.1111/j.1365-2133.2011.10633.x.
Many of today's treatments associated with 'thinning hair', such as female pattern hair loss and telogen effluvium, are focused on two of the key aspects of the condition. Over-the-counter or prescription medications are often focused on improving scalp hair density while high-quality cosmetic products work to prevent further hair damage and minimize mid-fibre breakage. Fibre diameter is another key contributor to thinning hair, but it is less often the focus of medical or cosmetic treatments.
To examine the ability of a novel leave-on technology combination [caffeine, niacinamide, panthenol, dimethicone and an acrylate polymer (CNPDA)] to affect the diameter and behaviour of individual terminal scalp hair fibres as a new approach to counteract decreasing fibre diameters.
Testing methodology included fibre diameter measures via laser scan micrometer, assessment of fibre mechanical and behavioural properties via tensile break stress and torsion pendulum testing, and mechanistic studies including cryoscanning electron microscopy and autoradiographic analysis.
CNPDA significantly increased the diameter of individual, existing terminal scalp hair fibres by 2-5 μm, which yields an increase in the cross-sectional area of approximately 10%. Beyond the diameter increase, the CNPDA-thickened fibres demonstrated the altered mechanical properties characteristic of thicker fibres: increased suppleness/pliability (decreased shear modulus) and better ability to withstand force without breaking (increased break stress).
Although cosmetic treatments will not reverse the condition, this new approach may help to mitigate the effects of thinning hair.
如今许多与“脱发”相关的治疗方法,如女性型脱发和休止期脱发,都集中在该病症的两个关键方面。非处方或处方药物通常侧重于提高头皮头发密度,而高质量的美容产品则致力于防止进一步的头发损伤和尽量减少中端纤维断裂。纤维直径是导致脱发的另一个关键因素,但它很少成为医疗或美容治疗的重点。
研究一种新型的免洗技术组合[咖啡因、烟酰胺、泛醇、二甲基硅油和丙烯酸盐聚合物(CNPDA)]对个体终末头皮头发纤维直径和行为的影响,作为一种对抗纤维直径减小的新方法。
测试方法包括通过激光扫描测微计测量纤维直径,通过拉伸断裂应力和扭转摆锤测试评估纤维机械和行为特性,以及包括冷冻扫描电子显微镜和放射自显影分析在内的机制研究。
CNPDA 可使单个现有的终末头皮头发纤维的直径增加 2-5μm,从而使横截面面积增加约 10%。除了直径增加之外,CNPDA 增厚的纤维表现出更厚纤维的特征性机械性能变化:增加柔软度/柔韧性(降低剪切模量)和更好地承受力而不破裂的能力(增加断裂应力)。
尽管美容治疗不会逆转这种状况,但这种新方法可能有助于减轻脱发的影响。