基质金属蛋白酶-9 的血浆水平：血管内动脉瘤修复成功的可能诊断标志物。
Plasma levels of matrix metalloproteinase-9: a possible diagnostic marker of successful endovascular aneurysm repair.
机构信息
Department of Surgery, Maastricht University Medical Center, The Netherlands.
出版信息
Eur J Vasc Endovasc Surg. 2012 Feb;43(2):171-2. doi: 10.1016/j.ejvs.2011.10.014. Epub 2011 Dec 14.
OBJECTIVE
The aim of the study was evaluating the diagnostic value of plasma matrix metalloproteinase- (MMP)-2 and -9 and tissue inhibitor of MMP-1 (TIMP-1) for endoleak detection after endovascular aneurysm repair (EVAR).
REPORT
Consecutive EVAR patients (n = 17) with endoleak and matched controls without endoleak (n = 20) were prospectively enrolled. Increased levels of MMP-9 were observed in patients with endoleak (P < 0.001). Regression analysis showed no significant influence of age, sex or abdominal aortic aneurysm (AAA) size. The receiver operating characteristic (ROC) curve of plasma MMP-9 levels showed that a cut-off value of 55.18 ng ml(-1) resulted in 100% sensitivity and 96% specificity with an AUC value of 0.988 (P < 0.001) to detect endoleak.
CONCLUSIONS
Plasma MMP-9 levels appear to discriminate between patients with and without an endoleak with high sensitivity and specificity.
目的
本研究旨在评估血管内动脉瘤修复（EVAR）后血浆基质金属蛋白酶-（MMP）-2 和 -9 及基质金属蛋白酶组织抑制剂-1（TIMP-1）对内漏检测的诊断价值。
报告
前瞻性纳入了 17 例有内漏的连续 EVAR 患者（内漏组）和 20 例无内漏的匹配对照患者（无内漏组）。内漏组患者 MMP-9 水平升高（P<0.001）。回归分析显示，年龄、性别或腹主动脉瘤（AAA）大小对 MMP-9 水平无显著影响。血浆 MMP-9 水平的受试者工作特征（ROC）曲线显示，55.18ng/ml 的截断值可检测出内漏，灵敏度为 100%，特异性为 96%，曲线下面积（AUC）值为 0.988（P<0.001）。
结论
血浆 MMP-9 水平似乎可以高灵敏度和特异性地区分有内漏和无内漏的患者。
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