修复慢性损伤肾脏：再生医学的作用

Repairing the chronic damaged kidney: the role of regenerative medicine.

作者信息

Caldas H C, Hayashi A P C, Abbud-Filho M

机构信息

Laboratory of Immunology and Experimental Transplantation-LITEX, Medical School, FAMERP/FUNFARME, Hospital de Base, Sao Jose Rio Preto, Brazil.

出版信息

Transplant Proc. 2011 Dec;43(10):3573-6. doi: 10.1016/j.transproceed.2011.10.053.

DOI:10.1016/j.transproceed.2011.10.053

PMID:22172807

Abstract

The increasing number of patients who suffer from chronic kidney diseases combined with the organ shortage have directed the attention of researchers to new alternatives in the fields of regenerative medicine including cell-based therapies and tissue bioengineering. This review of renal regenerative medicine addresses the mechanisms of action by stem cells to regenerate or repair chronically damaged renal tissue, alternative routes for their delivery, the role of biomaterials in tissue engineering, and the potential therapeutic effects of combining cell therapy with biomaterials. Despite the promise of ongoing work for therapy of chronic renal failure, caution is required as a large gap still exists between scientific knowledge and clinical translation for safe, effective stem cell-based therapies.

摘要

慢性肾病患者数量的不断增加以及器官短缺问题，促使研究人员将注意力转向再生医学领域的新替代方案，包括基于细胞的疗法和组织生物工程。这篇关于肾脏再生医学的综述探讨了干细胞再生或修复慢性受损肾脏组织的作用机制、它们的递送替代途径、生物材料在组织工程中的作用，以及细胞疗法与生物材料相结合的潜在治疗效果。尽管目前在慢性肾衰竭治疗方面的研究工作前景广阔，但由于在安全、有效的基于干细胞的疗法的科学知识与临床转化之间仍存在巨大差距，因此仍需谨慎对待。