Division of Urology, Saban Research Institute, Developmental Biology Program, Childrens Hospital Los Angeles, 4650 Sunset Blvd MS #35, Los Angeles, CA 90027, USA.
Adv Drug Deliv Rev. 2011 Apr 30;63(4-5):379-87. doi: 10.1016/j.addr.2010.12.001. Epub 2010 Dec 9.
End stage renal disease is a major health problem in this country and worldwide. Although dialysis and kidney transplantation are currently used to treat this condition, kidney regeneration resulting in complete healing would be a desirable alternative. In this review we focus our attention on current therapeutic approaches used clinically to delay the onset of kidney failure. In addition we describe novel approaches, like Tissue Engineering, Stem cell Applications, Gene Therapy, and Renal Replacement Therapy that may one day be possible alternative therapies for patients with the hope of delaying kidney failure or even stopping the progression of renal disease.
终末期肾病是这个国家和全球的一个主要健康问题。虽然透析和肾移植目前用于治疗这种疾病，但导致完全治愈的肾脏再生将是一种理想的替代方法。在这篇综述中，我们将注意力集中在目前临床上用于延迟肾衰竭发生的治疗方法上。此外，我们还描述了一些新的方法，如组织工程、干细胞应用、基因治疗和肾脏替代治疗，这些方法有朝一日可能成为肾衰竭患者的替代治疗方法，有望延迟肾衰竭甚至阻止肾脏疾病的进展。
