Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.
Eur J Pharmacol. 2012 Feb 15;676(1-3):1-5. doi: 10.1016/j.ejphar.2011.11.044. Epub 2011 Dec 7.
In eukaryotes, many translation inhibitors have been widely used as bioprobes to evaluate the contribution of translation to signaling pathways and cellular functions. Several types of translation inhibitors are also known to trigger the activation of the mitogen-activated protein kinase superfamily in an intracellular mechanism called ribotoxic stress response. This perspective focuses on the biological properties of recently identified translation inhibitors that trigger ribotoxic stress response, particularly glutarimides as well as triene-ansamycins.
在真核生物中，许多翻译抑制剂已被广泛用作生物探针，以评估翻译对信号通路和细胞功能的贡献。几种类型的翻译抑制剂也已知会在一种称为核糖体毒性应激反应的细胞内机制中引发丝裂原激活蛋白激酶超家族的激活。本观点侧重于最近发现的触发核糖体毒性应激反应的翻译抑制剂的生物学特性，特别是戊二酰亚胺和三烯-安丝菌素。
