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展神经(第六对脑神经)麻痹表现为一种罕见的原发性乳腺癌脑于孤立性转移病例。

Abducens (sixth) nerve palsy presenting as a rare case of isolated brainstem metastasis from a primary breast carcinoma.

机构信息

Neuro-Ophthalmology Service, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433.

出版信息

Singapore Med J. 2011 Nov;52(11):e220-2.

Abstract

Most isolated abducens (sixth) nerve palsies are ischaemic in nature. However, there are other causes that can mimic an abducens nerve palsy, which requires aggressive diagnostic management. A 56-year-old hypertensive woman presented with a right abduction deficit. Her past history revealed that she had undergone a mastectomy and completed a course of chemo- and radiation therapy for breast carcinoma. She was well until she develped binocular diplopia five months later. Magnetic resonance imaging showed a right pontine mass. Stereotactic biopsy was performed, and histopathology revealed a metastatic carcinoma that was compatible with an origin from the breast primary. We conclude that identifying and managing patients with metastatic lesions involves a multidisciplinary approach. Thorough history-taking and neuro-ophthalmologic evaluation would help physicians in establishing the primary differentials, which could not only be sight-saving but life-saving as well.

摘要

大多数孤立性展神经(第六对脑神经)麻痹是缺血性的。然而,还有其他一些原因可以模仿展神经麻痹,这需要积极的诊断管理。一位 56 岁的高血压女性出现右侧外展神经麻痹。她的既往病史显示她曾接受过乳房切除术,并完成了乳腺癌的化疗和放疗疗程。直到五个月后她出现双眼复视,她才出现不适。磁共振成像显示右侧桥脑有一个肿块。进行了立体定向活检,组织病理学显示转移性癌,与乳腺原发性癌相符合。我们的结论是,识别和治疗转移性病变的患者需要多学科方法。详细的病史采集和神经眼科评估将帮助医生确定主要的鉴别诊断,这不仅可以挽救视力,还可以挽救生命。

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