School of Experimental Psychology, University of Bristol, 12a Priory Road, Bristol, BS8 1TU, UK.
Psychopharmacology (Berl). 2012 Jun;221(4):551-60. doi: 10.1007/s00213-011-2601-0. Epub 2011 Dec 17.
Caffeinated alcoholic beverages have been associated with increased risk of alcohol-related harms. However, few studies have examined these combined effects on behavioural control, which is believed to underlie many of the negative effects of alcohol consumption. In addition, studies have often omitted subjective measures, and none have directly assessed the role of caffeine consumer history.
To examine the combined effects of alcohol and caffeine on measures of behavioural control and perceived intoxication in abstinent, light caffeine consumers.
Participants (n = 28; 50% male) attended four sessions at which they consumed one of the following beverages in a randomised order: placebo, alcohol alone (0.6 g/kg), caffeine alone (2.0 mg/kg), and alcohol/caffeine. They completed measures of mood, intoxication, anxiety and alcohol craving before and after a task battery comprising measures of behavioural control and reaction time performance.
Caffeine attenuated alcohol-related performance deficits on stop-signal accuracy, had no effect on go-no-go performance deficits, and worsened accuracy on the Stroop task. Caffeine did not influence absolute changes in perceived intoxication but there was suggestion that caffeine may have changed the nature of intoxication with increases in stimulation.
Caffeine appears to have mixed effects on alcohol intoxication that are task-dependent. We found increased stimulation in the alcohol/caffeine condition, supporting the contention that caffeinated alcoholic beverages enable an individual to drink for longer. Future research should model real world drinking behaviour by examining how these effects change across multiple drink administrations.
含咖啡因的酒精饮料与酒精相关伤害的风险增加有关。然而,很少有研究检查这些组合效应对行为控制的影响,而行为控制被认为是酒精消费的许多负面影响的基础。此外,这些研究通常忽略了主观测量,并且没有直接评估咖啡因消费者史的作用。
研究酒精和咖啡因对禁欲和轻度咖啡因消费者的行为控制和感知醉酒的综合影响。
参与者(n=28;50%为男性)参加了四个会议,在这些会议中,他们以随机顺序饮用了以下饮料之一:安慰剂、单独的酒精(0.6 g/kg)、单独的咖啡因(2.0 mg/kg)和酒精/咖啡因。他们在完成行为控制和反应时间表现的任务后,在完成任务之前和之后完成了情绪、醉酒、焦虑和酒精渴求的测量。
咖啡因减轻了酒精相关的停止信号准确性的表现缺陷,对去-不去表现缺陷没有影响,并且降低了 Stroop 任务的准确性。咖啡因对感知醉酒的绝对变化没有影响,但有迹象表明,咖啡因可能通过增加刺激来改变醉酒的性质。
咖啡因似乎对酒精中毒有混合影响,这取决于任务。我们发现酒精/咖啡因条件下的刺激增加,支持了含咖啡因的酒精饮料使个体能够更长时间饮酒的观点。未来的研究应该通过检查这些效应在多次饮酒管理中的变化来模拟现实世界的饮酒行为。